Saturday, January 26, 2008

An Antiviral Mechanism

A HUM-MOLGEN news item titled, Tethering HIV and dated January, 24 2008, discusses an antiviral molecule known as tetherin. Tetherin is able to inhibit the release of HIV-1 from cells. A protein identified as CD317 (renamed tetherin) tethers HIV particles to cell surfaces and halts the viral release.

On the viral side the HIV protein Vpu facilitates the release of viral particles by neutralizing CD317. The molecular struggle can determine the immunological fate of an infected individual.

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